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See also allergy; atopy.
The immunological influences of early exposure to these antigens may have profound effects on subsequent susceptibility to allergy, atopy and risk of infection and disease later in life [1].
They also found that a history of allergy, atopy (eczema, asthma, and hayfever), corneal injury, eye rubbing, and rigid contact lens usage has been shown to be associated with the development of keratoconus.
For this study we included those patients who were generally healthy or had only minor medically compromising conditions such as allergy, atopy, asthma, or a history of recurrent otitis, adenotomy, or tympanostomy.
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In order to assess the possibility of effect modification of studied associations with the report of allergy and atopy, we included interaction terms between the report of allergy and atopy and the exposure variables and we performed stratified analyses.
In order to assess the possibility of effect modification by reported allergy or atopy, we included interaction terms between the exposure variables in the models and reported allergy and atopy.
All MS4A genes are clustered on chromosome 11q in humans [20] (chromosome 19 in mice) in a region with linkage to allergy and atopy [21].
Several studies have linked probiotic species with immunomodulation [14], [15], [16], [18], [19], [20], [21] and demonstrated their efficacy in protection against development of allergy and atopy.
Among the normal or rhinitis subjects without nasal polyps (n = 17), 4 had physician-diagnosed allergic rhinitis (AR), 2 had suspected AR, 1 had suspected vasomotor rhinitis, and 10 had no signs of nasosinus disease, allergy, or atopy.
Nevertheless, there are potential general implications from this LGG-focused study which demonstrate that high abundance of this species is associated with a dramatic change in GI microbial community composition, impacting the relative abundance of a large number of taxa previously associated with either an increased or decreased risk for the development of allergy and atopy.
In this context, characterizing the ontogeny of human immune responses including the contribution of innate immunity, provides insight into susceptibility of newborns and infants to infection, assesses immune polarization that may affect risks of allergy and atopy [13], and may inform development of age-specific adjuvanted vaccines [7].
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