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Endotoxin exposure has been proposed as an environmental determinant of allergen responses in children.
PDE4 inhibits both the inflammatory mechanisms and inhibits the regulatory networks that inhibit allergen responses.
It causes bronchoconstriction and airway inflammation and may therefore exacerbate allergen responses.
We found no significant differences between the bronchial allergen responses after formaldehyde exposure compared with exposure to air-only.
Our aim in this study was to investigate whether exposure to a low level (500 μg/m) of formaldehyde enhances inhaled allergen responses.
In view of the inconsistent literature data on whether high or low doses enhanced or suppressed the allergen responses, we chose a relatively high dose (30 μg·mL−1) for these studies.
Similar(49)
The administration of food allergens via mucosal routes, a procedure known as "mucosal immunotherapy," has provided encouraging results suggesting that mucosal immunotherapy is able to modify the host anti-food allergen response to reduce the severity of allergic responses.
Additionally, transcriptional profiling was carried out to determine the effect of inhibition of cPLA2α on the in vitro allergen response of asthma and healthy subjects.
Andersson et al. (2004) showed that maturation of newborn immature dendritic cells with LPS reduced the development of a TH2-associated birch allergen response.
Defects in epithelial barrier function are associated with human disorders in multiple organs including atopic dermatitis, allergen response in respiratory tracts, and gastrointestinal inflammation (Segre, 2006).
However, there was a tendency toward a lower immediate bronchial allergen response after exposure to formaldehyde compared with air-only, contrary to expectations.
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