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It is necessary to add major allergen measurements to standardization requirements to design adequate dosage schemes and elucidate the dose-response relation between major allergen dose and therapeutic effect.
By contrast, an animal that is resistant (Raai) would not develop symptoms regardless of allergen dose.
Hence, clinical efficacy appears to depend on the allergen dose.
Overall, treatment efficacy appears to be determined by the allergen dose.
Apparently, the concentration of house dust and the affiliated allergen dose was too low to elicit nasal symptoms.
Similarly, a 30-min exposure to 500 μg/m NO2 increased the early-phase response to an otherwise nonsymptomatic allergen dose (Strand et al. 1998).
Similar(49)
Responses between the two groups to lower allergen doses were not significantly different (Figure 3A).
For both groups there was an increase in skin flare size at the latter study day to allergen doses of 1.5 and 0.75 µg/mL (p = <0.001,in both groups at both concentrations, Figures 3B and 3C).
The additional exposure to ASA also impacted the severity of skin flare responses of control pigs; a trend for increased skin flare responses was seen at allergen doses of 200 µg/mL (p = 0.059) and 100 µg/mL (p = 0.068) when measured on study day 70 as compared to study day 45 (Figure 3B).
These facts may provide an explanation for the still improvable therapeutic effects in previous clinical studies of EPIT 21, 22, 24 which required high allergen doses 25.
Therefore, SIT is limited to specially trained physicians, it requires the multiple application of increasing allergen doses to reach the therapeutically effective maintenance doses and thus only relatively few allergic patients can benefit from SIT.
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