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Considering the central role of AKT in CLL and ALL, we performed a screening study in an attempt to detect the mutation E17K/ AKT1 in these types of haematological malignancies.
To ascertain if any of the genes or putative regulatory regions identified by WGS of four patients were recurrently mutated in ALL, we performed target capture and deep sequencing of these regions in a cohort of 145 BCP-ALL and 23 T-ALL samples (Table 2 and Supp. Tables S1 and S4).
To extend the spectrum of known somatic variants in ALL, we performed whole genome and transcriptome sequencing of three B-cell precursor patients, of which one carried the t(12 21) Etranslocationnslocandon and two lacked a known primary genetic aberration, and one T-ALL patient.
Therefore, first of all, we performed a series of phonon calculations at the Γ-point phonon for polythiophene and its derivatives in order to check the structural stability.
First of all, we performed our study in a sample of patients recruited from an Headache Center that may not be representative of the general migraine population [22].
Since AmphiVent2 has not been previously characterized at all we performed an expression analysis using real-time quantitative RT-PCR.
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To provide current and precise estimates of outcome in children with multiply R/R B-ALL, we performed a more comprehensive follow-up study using pooled retrospective data collected from 24 TACL institutions in the US, Canada, and Australia.
After all we perform a parametric study on SFTE-FSS.
To determine the specificity of the α-Gpp-all antibody, we performed immunizing peptide-blocking experiments.
This result is very robust, as we detected this change in all the experiments we performed.
In all the animals we performed bilateral sciatic MCV.
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