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The low platelet recovery we observed in all three indications of transfusions probably resulted from fast consumption or destruction of exogenous platelets.
Platelet increments were generally low in all three indications, 10 (interquartile range 2 25), 11 (2–25), and 8 (0–21) × 109/L, respectively.
Platelet increments were generally low in all three indications, 10 (interquartile range 2 25), 11 (2–25), and 8 (0–21) × 10/L, respectively.
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An adjusted indirect comparison (frequentist approach) was conducted in all four indications and declined by IQWiG as the chosen comparators did not correspond to the appropriate comparators chosen by the G-BA.
The algorithm was developed by translating all six indications into logical programming.
It was the only medicine to be prescribed for all eight indications.
The conclusion that Durolane is non-inferior to Artz is robust, as all four indications more than satisfied 8% non-inferiority criteria (Table 2).
Funnel plots were created for all experiments in aggregate, and for the three indications for which greater than 20 experiments were analyzable.
Only the RRs of serious systemic adverse effects (defined as death or serious cardiovascular events such as acute myocardial infarction or stroke) and ocular adverse effects (defined as endophthalmitis, retinal detachment, or vitreous hemorrhage) from all three clinical indications were pooled.
Summarizing the results of multiple clinical studies on all three Infuse indications, it was stated that "on-label" use of the product is safe and effective in most cases, although there is a definite possibility of complications, as well as unsatisfactory results requiring resurgery.
Figure 1 represents the distribution of platelet transfusions according to pre-transfusion platelet count in those three indications.
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