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For each level of those factors, a mean ROC-AUC value was calculated as an average across all the replications considering that level.
The search recovered 90 most parsimonious trees of 1313 steps, with a consistency index (CI) of 0.3679, a retention index (RI) of 0.7706, and the best score hit in all the replications.
The SCMR was recorded using SPAD-502 (Minolta Corp., Ramsey, NJ, USA) in all the experiments with two plants per plot and on two fully developed leaves per plant in all the replications.
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The two most stable control genes, GAPDH and HPRT, were used by qBase to normalise the expression values of all the replication and repair targets.
In each step, JBSPhaseController instructs JBOriginController to initiate licensed origins as appropriate and then instructs JBForkController to advance all the replication forks.
In contrast to the language-impaired cohort, all the replication SLI probands met the SLIC inclusion criteria described above with the exception of criterion (1) a normal karyotype, as the replication cohort were not karyotyped.
The results for each trait are presented in Table 5 and Figure 2. Meta-analysis across all the replication cohorts (n = 14,451) revealed significant independent association with SBP (p = 0.007).
These are the most telomere-proximal of all the replication origins in the fission yeast genome.
In a combined fixed-effect inverse variance meta-analysis of all the replication cohorts, rs2286885 was associated with IOP (P = 0.003) (Fig. 3).
All the replication timing data is from cells that have a serious S phase defect, and reviewers agreed that even though the authors have done a considerable amount of work on this aspect, they were not convinced that the conclusions were substantiated by the data.
Virtually all of the replication fork proteins in the I2 cluster were lost or were greatly perturbed when replication was inhibited.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com