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This analysis has been carried out by changing the value of each parameter from − 20 to 20%—but one parameter at a time with all the remaining parameters retaining their initial values (Table 1).
In this way, the SAR can be calculated using Equation 6, since all the remaining parameters are known.
These results have been obtained by using Eq. (6.7) with (C^{ (0 )}=C^{ (1 )}=C^{ (2 )}=0) (while all the remaining parameters are those of Table 1).
For all the remaining parameters the default Bowtie 2 values were used.
For each model, all the remaining parameters are estimated based on the number of nodes and edges of the target network.
For model identification, the parameters (and/or constants) for one class are required to be set to zero, such that all the remaining parameters are interpreted as being relative to this class.
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Default settings were used for all of the remaining parameters.
To estimate Type I error rates of testing H 0 β 1=0 vs H 1 β 1≠0, all the simulations were repeated by generating data using β 1=0, but keeping all the remaining parameter and covariate values the same as described previously.
The term E* xi±0.1xi) is the error computed from setting parameter xi to 10% above and below its optimal value and reoptimizing all of the remaining parameter estimates.
The second criterion relaxes the uniform diagonalizability requirement for the amplification matrix: The uniform diagonalizability is needed only in some subregion of the parameter values, and for the remaining parameter values, all the eigenvalues of the amplification matrix should be strictly less than unity in modulus.
We have cast three of the four parameters in terms of the remaining parameter and all the parameters are temperature independent.
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