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This systematic review assessed the quality of all the randomised controlled trials (RCTs).
For each specialty and subspecialty we calculated, separately, the number of journals that would need to be read to locate all the randomised trials and systematic reviews as well as the number to locate half of the randomised trials and half of the systematic reviews (which we designate the J50 value).
The impact of revascularisations on outcomes can be estimated from the pooled analysis of all the randomised trials where patients were randomised to an interventional strategy as a routine, or to a selective strategy based on symptoms and ischaemia.
All the randomised controlled trials (in adults and young people) directly compared (and randomised participants to) lower versus higher fat intake and measured absolute or changes in body fatness outcomes.
All the randomised studies except onew1 provided follow-up data at three months, at a minimum.
All the randomised patients will be analysed for the toxicity of the procedure.
Similar(42)
Intention-to-treat analyses that included all of the randomised patients were performed.
Ideally an intention to treat analysis would be carried out on all of the randomised subjects, but there is usually some missing primary endpoint data that prevents this.
We expressed incidence as the ratio of all trials that used the modified intention to treat approach over all the published randomised controlled trials in each year.
To summarise these results, all the recent randomised trials using later generation cytotoxics have not had a significant impact on standard care for SCLC, failing to identify a new platinum-based combination over the established platinum etoposide.
The intent-to-treat (ITT) population included all patients in the randomised treatment arms (standard dose/dose escalation), excluding patients ineligible for randomisation following the run-in period.
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CEO of Professional Science Editing for Scientists @ prosciediting.com