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However, as each of the SFARI genes may contribute to different processes, and participate in diverse phenotypes, not all the functionally related genes should be necessarily implicated in autism spectrum disorders.
By contrast, phylogenic analysis seems to be a strong predictor of the anthocyanin regulatory MYB proteins, with all the functionally proven anthocyanin specific MYB transcription factors falling into the same subgroup [ 15, 42– 42].
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A test suite is considered to be good if it distinguishes between the original description and all of the (functionally non-equivalent) mutants.
All of the functionally enriched GO terms identified thus far for those genes up-regulated at 24 and 48 hrs p.i. appeared to be closely involved in either genomic transcription (i.e., TFs, sequence-specific DNA and/or double-stranded RNA binding, oligopeptide transporter, and protein dimerization) or inflammatory responses (Figure 4A).
In silico analyses revealed that all of the functionally characterized human Cx50 missense mutations alter highly conserved residues (Supplemental Figure 1; multiple sequence alignment provided as supplementary text).
By contrast, Ire1 is well conserved in S. pombe, with all of the functionally important hallmarks identified in other eukaryotes, including its ER lumenal unfolded protein sensing domain and its cytosolic kinase and RNase domains.
All data on the functionally characterized genes annotated in this study were compiled in OGRO (http://qtaro.abr.affrc.go.jp/ogro).jp/ogro
Based on the observation of PPCs, we built a weighted network of synchronization (WNS), an all-to-all functionally connected network where each link is weighted by the PPC of two oscillators at the ends of the link.
We define a weighted network of synchronization as an all-to-all functionally connected network where each link is weighted by PPC of two oscillators at the ends of the link.
First, protein sequence comparison showed that Tc-MYBPA was most similar to the grape PA transcriptional regulator VvMYBPA1 and shared the conserved motifs of all the other functionally characterized R2R3-MYB PA synthesis regulators.
In all these cases, the functionally important residues and sequence motifs were found to be fully conserved with respect to the template.
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