Pax5+/− mice developed clonal pB-ALL recapitulating the clinical, histopathological and molecular features of human pB-ALL.
However, in order to test whether the results presented above are sensitive to parameters, we have performed a series of perturbation experiments in which parameters were randomly modified during evolution and found that the observations presented were all recapitulated in the perturbed networks (see Methods).
Notably, CD22ΔE12-transgenic (Tg) mice spontaneously develop B-lineage ALL which recapitulates the gene expression profile of CD22ΔE12+ human B-lineage ALL, establishing a causal relationship between CD22ΔE12 and B-lineage ALL and indicating that CD22ΔE12 is an oncogenic "driver lesion" sufficient for leukemogenesis (Uckun et al., 2014a).
Feathers have been ruffled: Robert Gottlieb, the New York Observer's dance critic, found Aronofsky guilty of "recapitulating all the old ugly misrepresentations of ballet", and of portraying ballet as one great "sadomasochistic trip".
The spontaneous metastasis model has the advantage of recapitulating all the important steps of the entire metastatic cascade, providing a unique platform to dissect the molecular mechanisms underlying all of the individual steps of metastasis.
Rather than recapitulating all of their points, I just want to draw three Christie-Ryan contrasts.
When cultivated as embryoid bodies (EBs), murine ES cells differentiate into mesenchymal progenitor cells, which progressively develop into mature, hypertrophic chondrocytes and transdifferentiate into calcifying cells recapitulating all of the cellular processes of chondrogenesis.
Animal models for AMD, although useful in some respects, fall short of recapitulating all aspects of the disease.
Importantly, clusters obtained using just the Y2H network are significantly worse using all measures in recapitulating functional modules and protein complexes.
Conversely, a single-minded focus on precisely recapitulating all aspects of a given human cancer for the purpose of drug testing has significant drawbacks as well.
Because of the complexities of AMD and the unique features of the human eye, animal models, although useful in some respects, fall short of recapitulating all aspects of AMD (Zeiss, 2010).
