NOTCH1 mutations alone or in combination with FBXW7 did not impact T-ALL prognosis.
In addition to the poor over-all prognosis the course of the disease is often complicated by thromboembolic events.
In our series the status of NOTCH1 mutations alone or in combination with FBXW7 did not impacted in T-ALL prognosis.
Given this evidence, we hypothesized that analysis of NOTCH1 in concert with genes functionally related to Notch1 pathway, such as FBXW7, KRAS and PTEN, would provide additional relevant information regarding T-ALL prognosis.
Since the first report addressing the role of NOTCH1 mutations in paediatric T-ALL prognosis, several controversial issues have been raised regarding the actual impact of these mutations on prognosis [ 7].
Aberrantly expressed FLT3 has been observed at high levels in a spectrum of hematologic malignancies, including 70% to 100% of AML, B-ALL, a fraction of T-Cell ALL, and CML in lymphoid blast crisis [ 31]; however, this is the first report that evaluated its potential role and association to B-ALL prognosis.
This involved 211 (81.2%) of all the prognosis papers.
It will be important to prospectively investigate EVI1 in paediatric ALL for prognosis on current treatment regimens, and potential therapeutic benefit.
For seven sweltering rounds, against all prognoses, Ali allowed Foreman, the brutish, one-blow Goliath, actually to punch himself out on his arms, as Ali himself lay on the ropes, head back as if out of a bedroom window to check if the cat was on the roof.
A remarkable part of Hazel's story is that she has been in hospice for longer than most patients, defying all prognoses on life expectancy.
