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Toward this end, we used the complete version of SNAP2 to predict effects for all possible variants at each residue position in our entire ALL set.
If it is impossible to test all possible variants, which products should be selected for testing?
Since only few of all possible variants can be tested at the developer's site, several questions arise.
Configurable products, like vehicles, face the challenge of handling all possible variants which are needed to answer the various customer needs.
Such sequences for a protein family comprise only a small fraction of all possible variants, however, representing the fitness landscape with limited scope.
The degree of variant selection was assessed by comparing the strength of the measured and predicted α texture from high temperature β texture, assuming equal occurrence of all possible variants during β → α transformation.
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In variant-aware alignment mode, PALMapper builds an implicit representation of the reference genome that reflects all possible variant combinations that exist for a genomic region.
An alternative could be to use only two variant sets (i.e. SAM + PL_PRIM), which also results in improved Ti/Tv ratios (Ti/Tv =2.30), but is computationally less intensive than including all possible variant sets.
For about a year, I tried to collect all the possible variants of that phrase that I heard, because it seemed that in this island of teenspeak, English had morphed into something very strange, in which sense was conveyed almost according to the rules of Chinese, or some other tonal language.
The surface antigens of trypanosomes are variable; only one or two of the many different variants are present in the blood at any one time and, unless one would possess mixtures of antibodies to all the possible variants, their detection is not reliable.
However, even if allowing computationally efficient exploration of genetic interactions, a posteriori detection and heuristic search schemes cannot guarantee that the detected pairs of genetic risk factors will eventually be the most essential ones for the improved predictive power among all the possible variant combinations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com