The phrase "all perturbed pathways of" is correct and usable in written English.
It can be used in contexts discussing complex systems, such as biology, physics, or mathematics, where pathways or processes are affected by disturbances or changes.
Example: "The researchers analyzed all perturbed pathways of cellular signaling to understand the impact of the drug."
Alternatives: "all disrupted pathways of" or "all altered pathways of".
Moreover, attenuation of TCRζ-dependent signaling will perturb pathways of antigen-dependent activation-induced cell death.
On the other hand, the most interesting finding of our study comes from Signaling Pathway Impact Analysis which showed that out of nine potentially perturbed pathways in two analyzed groups it is natural killer cell mediated cytotoxicity which is inhibited in eutopic endometrium of patients with endometriosis.
Through this DBN computational approach, the method identified significantly perturbed pathways and GO category groups of genes that define the pathogenicity signatures of the infectious agent.
Genes that were involved in any of the significantly perturbed pathways and changed beyond one standard deviation from the mean of all genes were subject to hierarchical clustering (Pearson correlation) and are presented on the heat maps using gplots package [ 56].
Malignant tumors often share a core group of about a dozen perturbed pathways [7] that regulate specific aspects of oncogenesis and tumor metastasis and thereby affect cell fate determination, cell survival, and genome stability [8].
These findings suggest that therapeutics might be chosen that target genes at critical points in the commonly perturbed pathway(s) of a group of patients.
Highly perturbed pathways included those implicated in antigen-dependent B-cell activation and the synthesis of leucine.
In the third case of this model, pathway-centric personalized cancer therapies can represent combined therapies targeting different perturbed pathways.
The principle of personalized cancer therapy is to develop therapeutic strategies targeting specific genomic alterations and/or perturbed pathways associated with specific cancers.
Canonical pathways and tox list (list of genes associated with toxicities as determined by IPA) with p-value ≤0.05 were deemed significantly perturbed pathways.
