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Each pathway was used as the outcome variable in a linear regression with all other pathways as predictors, and the pathway with the highest R2 was removed.
The contributions to total exposure from all other pathways, including outdoor air, were relatively small.
All other pathways took less than 8 minutes each to calculate.
We confirm the original report and extrapolate the oscillatory pattern to all other pathways.
Second, the differences in metabolic gene expression predicted the magnitude of differences for signaling and all other pathways, i.e. tissue samples with similar expression levels of metabolic transcripts did not show any differences in gene expression for all other pathways.
The majority of all other pathways displayed similar expression levels with an overall mean coverage close to 50.
Similar(43)
This test calculates the probability that genes participate in a given pathway, relative to their occurrence in all other pathway annotations covered by Ingenuity.
The microarray data showed that WGE altered axongenesis/neurogenesis, nervous system development, and dopamine secretion pathways in cortex and hippocampus, from the evidence that they yield the lowest p-values from all other pathway matches with the KEGG database.
The pathway comprises three enzymes (encoded by araBAD) that shunt l-arabinose into the pentose phosphate pathway, a low-affinity transporter (encoded by araE), a high-affinity transporter (encoded by araFGH), and a dual transcription regulator (encoded by araC) that upregulates the expression of all other pathway components when bound to l-arabinose (SI Figure S1A).
From the pathways listed in Table 3, we identified xenobiotic metabolism signaling as the key of all the pathways because all the other pathways are involved in xenobiotic metabolism signaling.
In each analysis several pathways were found to be markedly more significant than all the other pathways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com