Exact(3)
This test calculates the probability that genes participate in a given pathway, relative to their occurrence in all other pathway annotations covered by Ingenuity.
The microarray data showed that WGE altered axongenesis/neurogenesis, nervous system development, and dopamine secretion pathways in cortex and hippocampus, from the evidence that they yield the lowest p-values from all other pathway matches with the KEGG database.
The pathway comprises three enzymes (encoded by araBAD) that shunt l-arabinose into the pentose phosphate pathway, a low-affinity transporter (encoded by araE), a high-affinity transporter (encoded by araFGH), and a dual transcription regulator (encoded by araC) that upregulates the expression of all other pathway components when bound to l-arabinose (SI Figure S1A).
Similar(57)
Each pathway was used as the outcome variable in a linear regression with all other pathways as predictors, and the pathway with the highest R2 was removed.
The contributions to total exposure from all other pathways, including outdoor air, were relatively small.
All other pathways took less than 8 minutes each to calculate.
We confirm the original report and extrapolate the oscillatory pattern to all other pathways.
The majority of all other pathways displayed similar expression levels with an overall mean coverage close to 50.
Except for the HIF-1α pathway, all other pathways are present in the top 20 pathways extracted for subtypes by text mining (see Table 8).
On a long term basis (if the perturbation persists), even an effect on a single pathway will eventually have a ripple effect on all other pathways.
What if, instead of checkpoint abrogation, apoptosis would be inhibited in early-stage MDS whereas all other pathways downstream of the DNA damage checkpoint remain active?
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