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All of these methodological aspects are potential sources of bias.
All of these methodological shortcomings could be, and often were, compounded by deficiencies in quality of reporting.
All of these methodological weaknesses could be addressed by a suitably powered, prospective, randomised, placebo-controlled trial.
Two studies that did address all of these methodological concerns were those of data on myocardial infarction related mortality, which found a detrimental effect of heat 20 or of both heat and cold.
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Major elective surgery overcame many of these methodological limitations.
There are two implications of these methodological issues.
Most of these methodological problems could be easily addressed.
At DIMACS, we are investigating all these types of methodological and modeling issues.
All of these studies had methodological limitations (Tables 2 through 4).
All of these studies had methodological flaws and few compared the effect of exercises in warm water with exercises on land in RA [ 4, 5].
The three included trials were all of low methodological quality.
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