Exact(4)
Intention-to-treat analyses that included all of the randomised patients were performed.
Ideally an intention to treat analysis would be carried out on all of the randomised subjects, but there is usually some missing primary endpoint data that prevents this.
Given all of the randomised evidence on the effectiveness and toxicity of single agent cisplatin at 100 mg m−2, of the CAP (500, 50 and 50 mg m−2) combination and of all of the paclitaxel/platinum combinations, we conclude that optimal dose single agent carboplatin is a safe and effective first-line treatment for women with advanced ovarian cancer.
In the meantime, given all of the randomised evidence on the efficacy and toxicity associated with the regimens used in these trials, we conclude that single agent carboplatin is a safe and effective first-line treatment for women with advanced ovarian cancer.
Similar(56)
The impact of revascularisations on outcomes can be estimated from the pooled analysis of all the randomised trials where patients were randomised to an interventional strategy as a routine, or to a selective strategy based on symptoms and ischaemia.
4 5 Yet, a considerable limitation of all the randomised trials up to date is the lack of a uniform definition to describe poor ovarian responders.
For the purposes of the analysis, two types of population are to be considered: Per intention to treat (ITT): this population will consist of all the randomised patients.
Based on the combined analysis of all the randomised trials with long-term outcomes, this risk-related strategy has the potential to reduce the frequency of cardiovascular death and MI over the longer term.
Another potential shortcoming of our studies is the inability to exactly replicate all aspects of the randomised controlled trial independent of randomisation, such as exact dose of study drug, the role of placebos, the possibilities of differences in health care, and other differences between participants entered in randomised controlled trials and those in the general population.
Telephone calls will be made to all the cases of the randomised sample of the cohort.
The Full Analysis Set (FAS) consists of all patients of the randomised population who receive at least one dose of treatment in either group regardless of protocol deviations.
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