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Preclinical studies have demonstrated that infiltration of tumours by various stromal cell types, including immature myeloid cells [ 158, 159], endothelial progenitor cells [ 160] or fibroblasts [ 141] can all mediate resistance to VEGF-targeted agents in preclinical models (Fig. 4c).
To clearly characterize the impact of the evidence indication strength on the performance of SeeBot, we have conducted experiments in three cases with all weak, all mediate and all strong evidences to validate the SeeBot performance.
Participants' characteristics and values, including their knowledge and understanding of the test, resources to meet the test demands and their acceptance of these demands, as well as their perceptions of test importance and test difficulty, may all mediate washback (Green 2007).
The five identified, distinct point mutations in the head-domains of the α-actinin protein, all mediate increased actin cross-linking [10] [12].
Early on, it was recognised that OPN had adhesive activity, confirmed by the observation that its receptors all mediate cell adhesion.
Education, culture, language, and the characteristics of the health-related setting all mediate one's capacity to process health related information [ 1].
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It's just that they are all mediated by technology and the marketplace.
John Coltrane's style has been an amplifier for four decades of saxophonists: they plug themselves into it, and though different things come out, they're all mediated by the same source.
They are composed of different cell types, interacting with each other, with the extracellular matrix (ECM) and the surrounding tissue through a complex network of signaling pathways, all mediated by cell surface proteins.
These responses are all mediated by multi-protein complexes [ 4, 5].
Remarkably, this wealth of developmental effects is all mediated through the same primary signaling pathway [ 5].
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