Exact(7)
The MiP production was similar for all formulations with a peak activity of 36 µmol min−1g−1 for F1.
Thus, the bi-exponential was the best model to describe the release profile for all formulations, with correlation coefficients higher than 0.99 (Table 1).
The MnP was similar for all formulations, with a peak activity of 155 µmol min−1g−1 on day 15 for F1.
All formulations with PfAMA1 were immunogenic and induced functional antibodies.
In addition, it was well tolerated in all formulations with no significant safety issues.
Moreover, the ChS was entirely released in PBS in all formulations, with the exception of the non-native HA binding peptide.
Similar(53)
However, among all formulations prepared with constant HPMC K4M concentrations, F6 formulation which contained higher concentration of PVA, possessed more swelling ratio.
The results demonstrate that all formulations converge with similar accuracy in the case of an analytically-solvable test problem.
Figure 2 shows that all formulations loaded with Dox concentration from 0.03 to 18.75 μM inhibited the growth of HepG2 cells in a dose-dependent manner.
All formulations prepared with 3% of PVA showed optical transparence and mechanical properties suitable to be easily "peeled" after application (Figure 1a), whereas dispersions with 2% of PVA are too fluids to be handled (Figure 1b).
In vitro release studies demonstrated a triphasic release; initial burst release with two subsequent sustained release phases with most of the drug being released after 24 h (86.7%) Biological evaluation studies confirmed the tolerability of all formulations tested with release kinetics modelling results showing drug release was via quasi-Fickian or Fickian diffusion.
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