These proteases often collaborate in complex proteolytic networks that encompass upstream initiators and downstream efforts, where upstream members of the Caspase family cleave and activate downstream members.
These erroneous assignments could have adversely affected downstream efforts, causing markers to be incorrectly placed during the grouping and/or mapping stages of linkage map construction.
Short, modular synthetic pathways, for example, using the build/couple/pair (B/C/P) strategy, facilitate downstream efforts using medicinal chemistry.
By correction for population stratification, a GAS will be able to eliminate spurious genetic associations and thus avoid further fruitless downstream efforts.
Because there are no known feedbacks between tubulation and HGF signaling, this did not impair our downstream efforts to engineer cell signaling and communication; in fact, the tubulation acted as a convenient additional phenotypic output to indicate the presence of active HGF.
As the success rate of T cell epitope mapping projects critically depends on the quality of the selected set of putative epitopes used for T cell screening, this combination of in silico prediction and subsequent in vitro screening for peptide-MHC affinity represents a useful strategy to focus the downstream effort on those peptides that are most likely to represent true T cell epitopes.
In addition to working with China on security issues — including its role in Afghanistan, Iran, Pakistan and North Korea — Mr. Huntsman said climate change and the environment would be important parts of his efforts, because, "In today's world, we're all downstream".
All these efforts failed.
All these efforts proved fruitless.
All those efforts must continue, yes.
All these efforts have failed.
