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In particular, the heterogeneous effects of COPD on lung alveoli in different regions of the lung make it essential that large numbers of compartments are included in the model - for all datasets considered, matching between the simulation outputs and patient data was significantly improved as the number of alveolar compartments in the model was increased.
Figure 1 shows that the differences in survival are statistically significant for all datasets considered.
For all datasets considered here, primers were chosen to have amplification efficiency.
For the Jaccard index filter, the global Jaccard index in Equation (2) was calculated for a range of threshold values s, yielding a largely unimodal distribution of values for all datasets considered (Fig. 1 and Supplementary Figs S11 and S18).
Cox proportional hazard analysis of the three cohorts revealed that patients with breast tumours overexpressing FMR1 mRNA have an increased risk to develop lung metastasis (hazard ratio (HR) = 1.21; 95% CI 1.02 1.45, p = 0.0293) and this is independent from estrogen receptor status (HR = 1.51 95% CI 1.27 1.85, p < 0.0001), the only pathological parameter available for all datasets considered.
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So, intersections combining a large number of GeneChip models need to take a large number of genes into account to obtain the 50 most significant genes common to all the datasets considered.
However, as is evident from the results, the clustering performance of MOGASVM is the best among all the methods for all the datasets considered in this article.
However, to make it standard and consistent for all the datasets considered here, we have chosen the aforementioned parameter setting to obtain good clustering result within reasonable time.
With the goal of ranking genes in order of differential expression in mind, the combined p and median t methods perform well for all three datasets considered.
Tenfold cross-validation is performed in all the six datasets considered for evaluation.
We define biological gene evidence as all of the datasets considered as biological evidence, except alignment to other bee genomes, since we did not use information about genes or expression for the other bee genomes.
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