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In this study, we set out to answer this question by first of all ascertaining whether there are hyperphosphorylated tau aggregates in cortical and striatal tissues from patients with Huntington's disease, with comparison to cases with a known tauopathy (Alzheimer's disease, progressive supranuclear palsy, Pick's disease and corticobasal degeneration) and healthy control subjects.
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In our approach such an exclusion procedure is not needed and all ascertained familial data can be used in the statistical analysis.
More than one quarter of all ascertained cases in NNOs needed to be forwarded to the LPHA responsible for the cases' counties of residence.
32% of all ascertained incident cases of CRC were recruited to participate in SOCCS.
These eight families were all ascertained in the UK but other details of their geographical origins have not been provided.
Lung cancer concordance was estimated as the proportion of twin pairs with both twins affected of all ascertained twin pairs with at least one affected.
The cases from the three study populations were all ascertained from regional population-based cancer registries [ 3- 6, 12], although some patients were not available for the analyses.
Cases in Umeå were not ascertained by self-report, but identified via local and national diabetes and pharmaceutical registers, and hence all ascertained cases were considered to be verified.
Rather than self-report, cases in Denmark and Sweden were identified via local and national diabetes and pharmaceutical registers [ 26] (www.ssi.dk/Sundhedsdataogit/Registre/Diabetesregisteret.aspx, accessed 11 October 2013) and hence all ascertained cases were considered to be verified.
All ascertained SNPs including the R and r variants were tested for association with each hair color category (binary coded 0, 1) using logistic regression adjusted for gender and age.
MacEahern et al. [ 67] found that approximately 10% of all ascertained 50 K SNP chip polymorphisms that segregate in two taurine breeds (Angus and Holstein) also segregate in at least one of Bison, Yak, or Banteng.
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