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The differential expression patterns in Cx and Ox observed in microarrays analyses were validated for all selected genes.

DCE analyses were validated using Stata 14.1.

The theoretical analyses are validated by finite element analyses.

All models were validated through y-randomization (label scrambling).

All cell lines were validated through genotyping with an AmpF/STR Identifiler PCR Amplification Kit (Applied Biosystems, Carlsbad, CA, USA).

All collected sequence data were validated through a series of quality control steps.

These questionnaires were validated through experts' validation.

Analyses performed on the above gene expression dataset were validated through comparison with gene expression datasets GSE14905 and GSE13355 from the ArrayExpress database [ 47].

All cases of ovarian cancer included in the present study were validated through systematic verification across original medical records.

The preprocessed sequences were validated through quality assessment (Fig. 2).

Analytical results were validated through numerical simulations.

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