Studies on ethylene glycol alkyl ethers and related compounds administered to mice by oral gavage revealed the occurrence of testicular atrophy and decreased white blood cell count by EGM, EGdM, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate, and the toxicity was related to their chemical structure.
This suggest the formation of aromatic ether compound with one aryl and one alkyl group.
The compounds consisted out of a coumarin structure (MAO-B inhibitor) and benzyl-, piperidiN-benzylpiperidineidine- or p-bromo-N-benzylpiperizine moiety, resembling the N-benzylpiperidine function of donepezil (ChE inhibitor), connected via an alkyl ether linkage at the 7 position.
[(EO -3C-im][NTf2] was first synthEO -3C-imrough incorporating alkyl EO -3C-imety into the double imidazolium ring.
A foaming agent (6 mL, EMAL D-3-D, sodium polyoxyethylene alkyl ether sulfate, Kao Corp).
Aryl ether, alkyl ether, aryl amine, alkyl amine, aryl sulfide, alkyl sulfide, etc., which are all very important structural fragments in many chemical molecules, have an urgent need for better synthetic methods.
These classes also encompass anionic and cationic surfactants such as methylestersulphonate, olefinsulphonate, alkyl benzene sulphonates, alkyl ether sulphates, isotridecanolethoxylates, benzalkonium chloride, n-hexadecyltrimethy, and ammonium chloride.
Calculations consider ester, alkyl ether and vinyl ether linkages.
PA = phosphatidic acid; e = alkyl ether glycerol-alkyl chain linkage; p = plasmenyl glycerol-alkyl chain linkage; lyso = lysophospholipid.
PI = phosphatidylinositol; e = alkyl ether glycerol-alkyl chain linkage; p = plasmenyl glycerol-alkyl chain linkage; lyso = lysophospholipid.
PS = phosphatidylserine; e = alkyl ether glycerol-alkyl chain linkage; p = plasmenyl glycerol-alkyl chain linkage; lyso = lysophospholipid.
