Sentence examples for alk in from inspiring English sources

Among those tested, mAb13, mAb48 and mAb135 were found to recognize ALK-WT, but not ALK in which the GR had been deleted (ALK-delGR).

However, the high expression of ALK in ALK+ ALCL is due to the chromosomal translocation of ALK gene.

Could the discovery of ALK in familial neuroblastoma help children who didn't inherit the gene?

They also found ALK in some siblings who were healthy, making them wonder whether these youngsters were at high risk of neuroblastoma.

NT alone decreased AlK in the 0 5 cm soil layer, possibly by increasing POC, TOC and GRSPs, which were observed to play a role in reducing Al toxicity.

More and more we are seeing trials not just for the type of cancer you have, like breast, lung or colorectal cancer, but also for your genetic predisposition or gene mutation - like the BRCA gene in breast and ovarian cancers or ALK in lung cancer.

Taken together, our data suggest that constitutive ALK activity of CLTC-ALK fusion proteins induces similar survival and proliferative signalling cascades in DLBCL as NPM-ALK in ALCL.

LM1 can thus serve as pre-clinical testing platform for the role of CLTC-ALK in lymphomagenesis and developing molecular targeted therapy approaches for CLTC-ALK positive DLBCL.

These data indicate a role of CLTC-ALK in the maintenance of the malignant phenotype thereby providing a rationale therapeutic target for these otherwise refractory tumors.

Likewise, it was observed that expression of the oncogenic tyrosine kinase NPM-ALK in MEFs prevented the accumulation of cells as assessed by crystal violet assay (Figure 1B).

While ectopic expression of CLTC-ALK in fibroblasts induced less STAT3 phosphorylation than other ALK-fusion proteins [15], a recent immunohistological study detected ubiquitous STAT3 hyperphosphorylation in two CLTC-ALK positive DLBCL cases compared to ALK negative DLBCL [23].