In a multiple alignment of the 107 mature proteins, the Y/F/WxC-motif aligns in 104 of the sequences (Additional file 3: Figure S2).
The slot receiver -- basically a receiver who aligns in the space between the end of the offensive line and the widest receiver -- comes in all shapes and sizes.
Another reason Harper regularly aligns in the box is because he's a liability in coverage (we all saw his train wreck in the wild card loss at Seattle).
By constantly changing up Johnson's route tendencies and where he aligns in various formations, the Texans prevent a defense from finding a comfort zone and rhythm in its coverages.
And because a running back aligns in the backfield, most passes that he catches are shorter and easier; there's more space between a running back and defender before the snap.
This is where the evolution rises up: in the creative ways teams get the ball to the running back (or whichever playmaker aligns in the backfield – expect 99 percent of them to still be running backs since guys like Hernandez don't exactly grow on trees).
