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The facility must provide vibrational and thermal stability conditions for alignment-sensitive components.
The positioning stability error budget is developed for the alignment-sensitive components to provide connections between mechanical designs and performances of the support systems when they are subjected to multiple input sources that can cause structural vibration and drift.
Finally, the results confirm that all dominating and alignment-sensitive costs should be simultaneously evaluated in the alignment optimization process because many trade-off opportunities exist among those costs.
As discussed throughout this work, our methodology is inherently alignment-sensitive and simply cannot detect structural conservation if the input sequence is mis-aligned.
That said, each DO sample will have a unique set of SNPs and indels that can bias read alignment, and in total across a large population of DO mice, the number of alignment-sensitive genes will approach the sum of all genes that are sensitive to alignment bias across all of the eight founder strains.
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In terms of alignment sensitivity, SSEARCH with sensitive matrices is better than BLAST-based methods, partly because the BLAST algorithm including CS-BLAST, and also SSEARCH with MIQS.SCOP40-v, tends to generate shorter alignment (Supplementary Fig. S4).
Bensimon, A. et al. Alignment and sensitive detection of DNA by a moving interface.
The algorithm of multiple sequence alignment is sensitive to the flexible multiword.
Through the use of a custom high optical quality furcated fiber to improve light transmission, precise machining of a flow cell to reduce background stray light through precision alignment, and sensitive electronic circuitry to reduce electronic noise through an active low pass filter, the background noise level is measured in the tens of µAU.
Thus stretch-induced alignment is sensitive to stretch frequency over a range of two orders of magnitude, with the actual values of the threshold and saturation frequencies dependent on the value of τ.
Where possible we resolved ambiguous alignments with sensitive realignment.
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