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This alignment usually lasts for only a small portion of an afternoon.
When the sequence and template are not close homologs, their alignment usually contains displaced gap opening or ending positions.
Just as most work on defining SBs focuses on two genomes at a time, so is whole-genome alignment usually done pairwise.
The alignment usually involves a rigid transformation to superimpose the two sequences of points, and a mapping which specifies the matched points.
The quality of a TM model depends on the accuracy of sequence template alignment (Cozzetto and Tramontano, 2005; Sommer et al., 2006); this alignment usually contains errors when only distantly related templates are available for a protein sequence under prediction.
Both have the propensity for magnetic alignment, usually with the membrane normal directed perpendicular to the external magnetic field direction of an NMR spectrometer (which would be the vertical z-axis in Figure 2).
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Figure 2 shows that for S/D-homologous interfaces, Galinter alignments usually agree with I2I-SiteEngine alignments.
Protein sequence alignments usually rely on a substitution matrix.
Low-scoring alignments usually have fewer gaps and their score distribution differs from those obtained for high-scoring alignments with gaps.
In the first step, a candidate SNP set is obtained from alignments, usually in the BAM/SAM format, using a novel method 'dynamic matrix algorithm'.
We chose to use aligned sequences from only placental mammals, because our examination of OR region alignments in the UCSC Genome Browser revealed that placental mammal alignments are usually part of longer chained alignments, whereas apparently aligned sequences from other species are often fragmentary and confined to interspersed repeat elements.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com