Between the 1950s and 1990s, various alignments of US 301, US 301N, and US 301S followed DE 896.
With the re-alignment, US 160 was re-routed into Arizona instead of Utah.
Old Virginia Road (unsigned MD 250A), a section of old alignment of US 113, continues west to US 13 Business (Market Street).
The former alignment of US 1 along surface streets in Trenton was renumbered to US 1 Business, while the US 1 Alternate was dropped.
The former alignment of US 240 between Clarksburg and Frederick was designated as US 240 Alt.
Sections of old alignment of US 113 north of Berlin were designated MD 575.
In 1974, the Commodore Barry Bridge was built, bypassing the ferry, and the old alignment of US 322 became Route 324.
The current alignment of US 1 between Trenton and New Brunswick was chartered as the Trenton and New Brunswick Turnpike in 1803 and struggled throughout its 100-year existence.
MD 355 was designated onto the former alignment of US 240 between Bethesda and Frederick as each stage of freeway was built.
By 1924, the state highway along the present alignment of US 9 was completed, running from Laurel through Georgetown to Lewes.
was established in 1970, replacing the former alignment of US 13 through Wilmington that was shifted to bypass the city along the former US 13 Alt.
