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Individual repeat information cannot normally be garnered from fold prediction as all programs will, to varying degrees, tend to extend the query to template alignment substantially beyond the repeat segments, in particular if the adjacent regions are α-helical.
Transcriptome alignment substantially reduces target complexity by limiting it to known transcripts, including all possible splice isoforms (Li and Dewey 2011).
The moderate training time of around one man week increased the performance and quality of the word alignment substantially compared to when a purely statistical system or the ITools suite without training were used.
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Although SNP tolerance does not increase alignment yield substantially, it affects alignment results in 7 8% of transcriptional reads, typically by revealing alternate genomic mappings for a read.
Similar to previous studies, the use of genes or internodes with high bootstrap support or internode certainty values, both of which were positively correlated with gene alignment length, substantially reduced the observed incongruence.
Again, though the microfeatures were maintained at equivalent periodicity and amplitude for each composition based on the spatiotemporal reaction control afforded by photopolymerization, the SGN neurite alignment is substantially improved on the stiffest substrate compared to on the softest substrate.
These alignments differ substantially from glocal genome alignments, wherein all copies of a repetitive gene family may become aligned to each other.
The stQD values for the EST-like gappy alignments were substantially higher than for the full alignments, with a median approaching 0.4 in the case of MP.
As noted, the indicator method is of general utility and could readily be applied to longer sequences or concatenated multi-gene alignments without substantially increasing computation time, which might address some of these limitations.
Defining splicing graphs based on RNA-Seq data entails the additional difficulty that inaccurate or ambiguous read alignments can substantially increase the size of these graphs.
It is apparent that the level of inconsistency in structural alignments varies substantially between methods and that it can be partially explained by the structural complexity of the fold.
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CEO of Professional Science Editing for Scientists @ prosciediting.com