Sentence examples for alignment split from inspiring English sources

Detection of indels based on next generation sequencing (NGS) technologies is becoming more common [ 2], and current approaches include gapped alignment, split reads and de novo assembly [ 3].

We present ScanIndel, an integrated framework for detecting indels with multiple heuristics including gapped alignment, split reads and de novo assembly.

We believe a hybrid approach that integrates multiple signals from all three sources (gapped alignment, split reads and de novo assembly) allows for more sensitive indel discovery than methods examining merely one or two signals.

Mt. Zion Church Road, yet another old alignment, splits to the north in the hamlet of Laurel Grove before MD 235 intersects the eastern terminus of MD 6 (New Market Turner Road) and Morganza Turner Road in Oraville.

Since a phylogenetic tree is only as good as the underlying alignment, splitting the kinases into families prior to generating phylogenies is a more powerful method for comparing entire kinomes.

As reported in table 2, only for ALB both null models were rejected in favor of the positive selection models (after Bonferroni correction for two tests, to account for alignment splitting).

In order to visualize all available phylogenetic signals (36,724 aa in total) in the 127 ortholog alignments, split decomposition analyses were calculated with the computer program SplitsTree ver. 4 (Huson, 1998, Huson & Bryant, 2006).

Note that a duplication event involves a single local alignment because alignments split by insertion of repeats are chained right after obtaining LASTZ alignments by a preprocessing step of the CAGE pipeline (Song et al. 2010).

This approach allows us to report multiple overlap alignments (including split alignments) for an experimental map while using the q-value analysis, as before, to report all alignments with q≤0.01.

Validation and breakpoint detection were carried out using our previously developed pipeline, R-SAP (RNA-Seq analysis pipeline; [ 33]), that accurately detects fragmented alignments (split-mapping) representing potential gene fusions and/or genomic rearrangements.

Similarly, the alignment was split into three partitions, namely H4, spacer and H3.