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While MUSTANG alignment results in a 3.6 Å RMSD superposition (figure 5b), two conserved specific side-chain mediated hydrogen bonds responsible for FAD binding are identified at a sieving level as low as 0.5 Å (E218/D73 – FAD O2B/O3B; D481/D353 - FAD O3').
Adding non-native sequences to the native alignment results in a change of sequence profile for PSI-BLAST searches.
Failure of restoring alignment results in a malunited scaphoid which may lead to pain and restricted motion [ 2].
The described weak alignment results in a weak dipolar splitting on the order of Hz to several tens of Hz.
Applying a coevolution algorithm to an alignment results in a 'coevolution matrix,' where each position in the lower triangle contains a pairwise coevolutionary score.
The tumour microenvironment promotes the deposition of ECM proteins into cross-linked fibers, whose alignment results in a stiffer stroma and poorer prognosis for cancer (Fig. 3a) [ 76 ].
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However, when aligned to each of the 17 sequences, only one alignment resulted in a Z-score of 4 and all the other z-scores were ≤2.
Such improved conductivity and better energy alignment resulted in a simultaneous enhancement of short-circuit current density (Jsc), open-circuit voltage (Voc) and fill factor (FF) in CPEs modified devices.
Removal of both classes of sequence as well as correcting the structure alignment resulted in a more uniform mean local Zp as shown in Figure S1B.
Statistical parsimony analysis of the full ITS alignment resulted in a single, highly interconnected and largely unresolved network with maximum connection limit of 9 steps (Figure 3).
Furthermore, the large-scale structural variation also complicates DNA sequence alignment, resulting in a maize "reference" genome that contains only 70% or less of the species-wide genome space [12].
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