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Exact(27)
The alignment of each template residue in the structure-to-structure alignment produced by TM-align was compared with the alignment of the same residue produced by one of the methods.
Nucleotide sequences were aligned according to corresponding aminoacid alignment produced by MUSCLE (Edgar 2004), and frameshift mutations were corrected manually.
Upon closer inspection, the results of our experiment indicate a significant degree of disagreement between the respective scores: only in 28% of the 2500 pivot-versus-counterpart alignments, all three scores agree on whether the alignment produced by DALI or by TM-Align is the best.
It does not involve explicit use of a metric tensor, although such a tensor must exist for the method, and an interesting question to ask is whether or not the alignment produced by the metric gives an anisotropic mesh.
Certainly, the alignment produced by the proposed method seems to be good.
This phenomenon could be due to the incorporation of the DBT units into the PFO segments which hence leads to the better conjugation length and chain alignment produced by the PFO-DBT nanorod bundles.
Similar(33)
(3) Sites of local congruence were sought in multiple sequence alignments produced by CLUSTALW, ALIGN-M and DIALIGN, with various gap penalty options for the first two.
Inspecting the box-whisker plots at the same-Fold group, shows that a very large majority of alignments produced by DALI and TM-Align and scored using I-value are seen to be statistically significant (i.e. with Null– I-value message length > 0), with DALI alignments being more reliable than those generated by TM-Align, judging by the compression gain at the level of their respective medians.
It has, however, been shown that known regulatory elements are not always correctly aligned (Siggia, 2005), an issue that is further complicated by the different alignments produced by various alignment programs (Pollard et al., 2004).
Strong paramagnetism decreases with rising temperature because of the de-alignment produced by the greater random motion of the atomic magnets.
This information is then used to evaluate alignments produced by the mapper.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com