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We demonstrate the value of this framework for both the alignment of regulatory regions and the inference of precise binding-site locations within those regions.
A universal judgement was made by the three reviewers to add the features environmental climate (Table 3, no. 42) and alignment of regulatory framework (Table 3, no.
An alignment of regulatory and G-BA approaches therefore seems critical to provide patients with a clear understanding of the benefit-risk ratio.
Furthermore, the experts suggested five new features during this round (see Table 3, column 1): incentive systems (no. 43), community participation (no. 44), universal health coverage (no. 45), single point of access (no. 46) and alignment of regulatory frameworks (no. 47).
Alignment of regulatory subunits mediating eIF2aP dephosphorylation reveals that sequence conservation in the PPP1R15 family is limited to a stretch of ∼70 residues in their C-termini, which is also the only conserved region of these proteins predicted to be ordered by DISOPRED (Ward et al., 2004).
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Data used to construct the test data sets was drawn from 35 seed alignments of regulatory structured RNAs found in bacteria (Additional file 1: Table S1) from the RNA Families database (Rfam) [ 44].
A disadvantage of this method is its inability to detect species-specific regulatory mechanisms and the sensitivity to the alignment of the regulatory regions.
Some of them include: a serious deficiency of engineers; fragmented policies and poor alignment of national regulatory frameworks; cost of the technology and limited grid infrastructure.
The exploitation of standards is emphasised for the flexible alignment of the regulatory framework across nations and larger enterprises.
The important issues are flexible alignment of the regulatory framework for support of both arms' length and collaborative practices.
Alignment of the regulatory framework across countries is highlighted as beneficial by the interviewees for innovation and reduction of LCOE, which means that the decreased 'formality of processes' highlighted in the literature is not actually strictly addressed.
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