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Further studies have revealed that the CAM-mediated intercellular protein-protein interactions at synapses, are involved in the recognition and alignment of pre- and post-synaptic sites, trans-synaptic signaling, and the precise localization of neurotransmitter receptors and releasable vesicles.
Despite its prominent role in this process, it has remained unclear how unplugged/MuSK signaling initiates this highly coordinated alignment of pre- and postsynaptic structures, both temporally and spatially.
Postsynaptic accumulations of both TRPM1 and mGluR6 and the alignment of pre- and post- synaptic compartments were both preserved.
Using these signals for alignment of pre and post-FISH stacks seems to be the most reasonable approach, however, since here the same molecules are detected.
Phylogenetic trees were reconstructed using DNA alignment of pre and post-therapy NS5A sequences corresponding to each patient in the study.
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Furthermore, it pays at least lip service to "alignment" of pre-school standards with the state's academic expectations for the early grades.
Figure S2 shows alignment of pre-miRNAs of C19MC.
McClure was evaluating her alignments by assessing the correct alignment of pre-defined functional motifs.
The analysis and method strongly depend on prior subfamily knowledge and alignment of pre-classified seed families which would make the same approach less easily applicable to other families, at least in an unsupervised manner.
As shown in the alignment of pre-microRNA sequences in the largest previously defined microRNA family within the Dlk1/Gtl2 region [ 19], mir-159 (see Additional file 3), these differences are due to small sequence variations, shifts in the hairpin structures causing different cleavage sites and differences in the location of the mature microRNA within the hairpin (5' vs. 3' end).
Trans-synaptic interactions involving Neurexins and Neuroligins are thought to promote adhesive interactions for precise alignment of the pre- and postsynaptic compartments and organize synaptic macromolecular complexes across species.
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