trossulus mORFs, because of alignment issues, were calculated only on the part of the ORF following the poly-A sequence.
Research by PMI describes most problems in project performance as being the result of alignment issues.
Even in the best of times, paying $4,500 to $7,000 for braces (depending on the severity of alignment issues) is a stretch for many — not to mention the thousands that some spend on preparatory work.
The repaired cd00300 dataset has 13 sequences removed because of alignment issues (annotated in Table S2).
While a poor rating can be indicative of alignment issues, particularly in cases where other states have higher ratings, it may also be the case that the structures include some atypical feature (e.g. intrinsically disordered regions, included ligands, domain swaps or long interacting stretches), such that they fall outside of what the assessment methods are trained to deal with.
Second, we used a tract-based spatial statistics (TBSS) method to explore the alterations within the white matter skeleton of the patients, which can overcome some drawbacks of VBA such as alignment issue and smoothing issue [22].
After Bonferroni correction and manual examination of potential alignment issues, we found 79 genes presenting evidence of reduced ratio of polymorphism to divergence (1.83%, red dots in fig. 4 a), out of which 41 have been identified as hypothetical proteins without known function and 38 have well-known annotated functions (supplementary material and table S3, Supplementary Material online).
"I have talked with some of the West Coast senators and certainly we have an alignment of interests on a number of issues," Harris told the Los Angeles Times in a telephone interview.
"I have talked with some of the West Coast senators and certainly we have an alignment of interests on a number of issues," Harris told the Los Angeles Times in a telephone interview.
Increased gene variability may be relevant to particular diseases but also may be indicative of read alignment issues (often due the presence of gene duplicates) or may indicate the gene is functionally redundant and thus not functionally constrained.
The two nations' alignment on the issue of the South China Sea illustrates the emergence of a more forward-looking relationship, said Kim Ninh, the country representative in Vietnam for The Asia Foundation, which is based in San Francisco.
