Sentence examples for alignment of a broad from inspiring English sources

Implementing a center-wide precision medicine strategy at a major cancer center is a true multidisciplinary effort and requires comprehensive alignment of a broad screening strategy with a clinical research enterprise that can use these data to accelerate development of new treatments.

In reinforcing the conclusions from the simulation study, recent sequence-structure analyses of ITS2 data from lepidopterans permitted alignment of a broad taxonomic spectrum and yielded phylogenetic reconstructions that matched the resolution provided by analyses of COI and COII [69].

Alignment of a broad selection of POU2 and POU5F1 translated sequences (Additional file 1) showed almost no conservation within the N-terminal region between paralogs.

Through comparison of the results of each protein sequence alignment to a broad selection of databases, we were able in some cases to correct and improve upon the automated annotation, highlighting the importance of manual curation where possible.

However, here again the query sets used in the two types of methods are not directly comparable: TE Pfam domains are generally well conserved domains often validated by biochemical/structural analyses and the resulting HMM profiles are based on multiple alignments of a broad diversity of TE and/or viral proteins.

One of the features that differentiate siRNAs from miRNAs is their alignment to a broad region of the target gene, in contrast to miRNAs that generally align to only the 21- or 22-nt sequence matching the miRNA.

When collagen in this viewing plane has the punctate appearance and scattered distribution characteristic of longitudinal collagen cords, the mean value and variance of the colinearity are both low, whereas the angle of maximum alignment has a broad distribution.

The EMVC method can also be used for the general refinement of gene set collections, either to create versions of a gene set collection that are customized for a specific domain or to identify and entirely remove annotations that exhibit poor alignment with a broad selection of genomic datasets.

Whether directly involved in the project or not, it's often critical to the project's success to have alignment across a broad stakeholder group.

To extend the usefulness of contact prediction, we have designed a new meta-predictor (MetaPSICOV) which combines three distinct approaches for inferring covariation signals from multiple sequence alignments, considers a broad range of other sequence-derived features and, uniquely, a range of metrics which describe both the local and global quality of the input multiple sequence alignment.

The subgroup-specific residues at positions 2 and 78 of the HMG domain [30] are well conserved in the full-length HMG domain alignment of our broad sample of taxa, with only a few exceptions, and none of the exceptions occurs in the arthropods (Fig. 2).