Sentence examples for alignment mutation from inspiring English sources

L. Chen carried out the sequence alignment, mutation detection, selection pressure and conditional selection pressure analysis.

TREAT is optionally offered as part of a complete workflow for exome or targeted sequencing, providing users with a convenient method for integrated sequence alignment, mutation detection and results interpretation.

This data is reasonably independent from the training data, because all data analysis steps such as quality control, alignment, mutation calls, etc., which could have added a systematic bias, were performed by the authors of the original publications rather than by COSMIC.

In fact, there is evidence of RIP mutation among the expressed TE sequences; five unisequences could be aligned with the genomic consensus of copia-like integrase gene from a prior analysis of RIP in M. violaceum [ 32], and among these alignments mutations at RIP recognition sites were 2 to 3 times more frequent that to any other sites.

From these data, Mutagrator produced interlinked, static HTML webpages of two types: master protein pages (for each protein in the TK domain alignment with mutations), and detailed mutation pages (for each protein residue position).

When used to find de novo mutations in exome sequences from family trios, or to compare normal and diseased samples from the same individual, the new method, direct alignment for mutation discovery (DIAMUND), produces a dramatically smaller list of candidate mutations than previous methods, without losing sensitivity to detect the true cause of a genetic disease.

For each di- or trinucleotide at a given position in the consensus sequence of an alignment, the mutation frequency was computed as the number of sequence fragments with a transition mutation at that position divided by the total number of aligned sequences.

Complete descriptions of the sequence alignment and mutation detection methods are provided in Materials and Methods in Additional file 1. Mutations identified were only included in the analysis if classified as deleterious or suspected deleterious based on previously described criteria [ 15].

Multiple sequence alignment and mutation detection were performed as previously described [ 10].

Here, we introduce a new method, D iamund (direct alignment for mutation discovery), which takes a different approach to exome and whole-genome analysis, and as a result produces dramatically smaller sets of candidate mutations.

Moreover, a careful analysis of AQP sequences alignment and mutation experiments demonstrated that the single substitution of the Asn-60 with a Gly residue eliminates the anion permeability and greatly enhances the osmotic water permeability [ 18].