Exact(2)
These models are built for high specificity, with consideration of local gene context for putative family members used in the manual adjustment of HMM seed alignment membership and scoring cutoffs.
Hidden Markov Model construction follows manual review of multiple sequence alignment membership and alignment quality, inferred molecular phylogenetic trees, and cutoff scores, according to practices described for the TIGRFAMs project [ 17].
Similar(6)
All data including raw sequences, cluster memberships, cluster alignments, and alignments with homologous sequences are provided for the user to examine the source of annotations.
The paper "An Effective Big Data Supervised Imbalanced Classification Approach for Ortholog Detection in Related Yeast Species" proposes a supervised Pairwise Ortholog Detection (POD) approach by combining a set of gene pair features based on similarity measures, such as alignment scores, sequence length, gene membership to conserved regions, and physicochemical profiles.
In this paper, a set of gene pair features based on similarity measures (alignment scores, sequence length, gene membership to conserved regions, and physicochemical profiles) are combined in a supervised pairwise ortholog detection approach to improve effectiveness considering low ortholog ratios in relation to the possible pairwise comparison between two genomes.
Having reckoned that organized labor, both locally and nationally, is too weak, distracted and demoralized to put up much of a fight, store executives believe now is the opportune time to attack--that the stars are in alignment--that the UFCW membership is ripe for having its health package chipped away.
HMMs for each subfamily were used to determine subfamily membership and refine alignments.
Sceptics about euro membership compare the recent alignment to ships passing in the night.
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