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Exact(4)
For dubious cases we run an ICP to assert whether the coarse alignment is sufficient or not for the ICP to converge.
However, it has never been asked how to test if the information content of an alignment is sufficient to find a realistic model.
In this situation, local alignment is not attempted because the global alignment is sufficient, and thus there is no soft-clipping done.
The experimental results support therefore the hypothesis that, at least in the LCK case, the domain alignment is sufficient to characterize the peptides binding model and to achieve therefore a higher overall sensitivity.
Similar(56)
Taken together, these results confirm that the data in the full simulated alignments are sufficient to allow recovery of very nearly true trees, most of the time, using all three phylogenetic inference approaches.
The algorithm performs ungapped extension of the alignments as it is sufficient for the compartmentization and gaps in the final alignments are discovered using the target function of the refinement stage.
Such alignments can still be reported by our program as partial splicing or 'half intron' alignments, if there is sufficient sequence on one end to determine a splice site, but insufficient sequence on the other end for the other site.
However, the existence of a chimeric alignment is not sufficient to reliably classify a sequence as an amplification artifact.
If the quality of the alignment is not sufficient at this stage, it can be decided to resequence the sample.
Even when only a small fragment of the adapter is overlapping, as shown in (C), the overall alignment is easily sufficient to ensure reliable detection.
Importantly, we found no difference in protrusions stability between the two conditions, indicating that cell alignment is not sufficient to increase protrusions stability.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com