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The complete alignment is provided in Additional file 1: Figure S1.
The alignment is provided as Additional file 3 and the data set can be downloaded from http://www.gjpvanwesten.nl/proteindescriptors.nl/proteindescriptors
The alignment is provided as supporting info.
Our SSU rRNA alignment is provided in the Supplementary Material.
The alignment is provided in the supplementary materials [see Additional file 2].
(The style guide for the manual word alignment is provided in Appendix3).
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The statistics of changes made by this alignment are provided in Table 2.
Timings which include the time required for alignment are provided in Supplementary Figure S12.
GenBank accession numbers for data used in the alignment are provided in (Additional File 1: Table S2), and the data set was deposited in treeBASE (Study ID 13741).
Finally, ProtTest [ 44] determined that the best fit to the amino-acid alignment was provided by the JTT + Γ4 + I + F model [ 45].
The results of the entire sequence alignment are provided in the Additional File 1 and are summarized in Figures 2, 3, and 4. Previously, the conservation of the N-terminal FERM domain among human ERM proteins and their functional importance were described [ 10- 13].
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