But, encouraging such alignment is easier said than done.
Task alignment is easiest in small units—a plant, department, or business unit where goals and tasks are clearly defined.
If you have asked for input during the discovery and research phase, employees are more likely to see their feedback in the plans and alignment is easier". Advice You Can Use: Before the budget is exhausted on other things, be sure to have a robust plan for employee engagement and communication.
This often leads to situations where two regions of the alignment are easy to align, but are separated by a short stretch where the sequence identity is locally low, and for which a relatively small number of alternative alignments have to be considered.
While reasonably accurate structure-based alignments are easy enough to generate, owing to the strength of the structural signal, it is nonetheless very hard to objectively assess the relative merits of alternative structure-based alignments (Kolodny et al., 2005).
In all these tests, CPU time is an important metric, as any alignment task is easy to perform by brute force if an aligner is given unlimited computer resources.
From the self alignment, it is easy to get the partition of π(t) = { AG, AG}.
The most common procedure used in North America for computing the column effective length factor K is the Jackson Moreland Alignment Chart, which is easy to use even though it is based on cumbersome equations.
These solutions provide user-friendly environments in which navigation along alignments, etc. is easy and reliable.
Because the lamprey genome sequences are divergent from jawed vertebrate genomes, it was harder to align them with those of other vertebrates, although this type of alignment is reportedly easy to do between jawed vertebrate genomic sequences (e.g., [49], [50] (see also Figure S4).
