Sentence examples for alignment is difficult from inspiring English sources

The alignment is difficult to determine in ground experiments.

For relatively rigid objects such as the brain, software can successfully align images from MR, CT and PET, whereas in more flexible environments, such as the rest of the body, accurate alignment is difficult owing to the large number of possible degrees of freedom.

Alignment is difficult to perform because size variations occur near their 5' ends.

Custom Perl scripts were used to eliminate SNPs that formed clusters (>1 variant every 4 bases) to exclude hypervariable regions where accurate alignment is difficult.

Moreover, accurate inter-modality spatial alignment is difficult for EPI-based images, such as perfusion and diffusion maps, which suffer from nonlinear geometric distortion due to magnetic susceptibility variations.

Nucleotide sequence alignment was difficult except between close relatives, so phylogeny reconstruction was performed using translated amino acid sequences that were predicted to have fewer saturated sites.

Since these fragment alignments are difficult to be distinguished and ranked, we take all of them into consideration.

This relaxed definition of conservation was previously used by Gordân et al. (2010) and is especially relevant when studying more diverged species for which accurate multiple sequence alignments are difficult to generate.

For divergent sequences, alignment accuracy is difficult to assess and popular methods can disagree, such was demonstrated by the relatively low level of agreement between outputs for the ENCODE regions (Chen and Tompa, 2010; Margulies et al., 2007).

These results, together with an early result which shows a related problem called threading to be NP-hard [ 10], have traditionally led molecular biologists to believe that the structural alignment problem is difficult in general (e.g. [ 11- 13]), even though a PTAS exists for the problem under a broad class of distance measures [ 14].

Even though CENP-H depletion reproducibly abolishes the bias in chromosome alignment, it is difficult to tell whether this is the result of the k-fiber stabilization or (more likely) the result of very dynamic plus-ends, which makes any interpretation hazardous.