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We concatenated sequences only after the alignment instead of before aligning them to avoid falsely aligning sequences from different domains.
To improve the quality of the alignments we used multiple sequence alignment instead of pairwise alignment, aligning the sequences in 21,969 groups of 40 sequences.
In Japan, the conflicting environment has fostered close Japan-U.S. alignment instead of encouraging Asian reconciliation.
However, in the view of their band structures, type I band alignment instead of type II is generally achieved in these heterojunctions.
We expect that tools for rapid application development will be further improved and will play an increasingly important role to establish responsive IT-infrastructures where the application developer can concentrate on business process alignment instead of coding and debugging.
Note that for the local feature extraction, we just rotate the faces into an upright position for alignment instead of applying a projective transform to prevent unnatural distortion of local regions and then resize the facial image to 64 × 64 pixels.
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The time to align the homologs to the query might be reduced by using the alignments implied by the families as a starting point to search for local alignments, instead of using BLAST to realign the homologs to the query.
Based on multiple alignments instead of pairwise alignments, our RNAz-based approach has a significantly increased sensitivity and specificity.
For example, approximating the multiple alignment distribution by analyzing the set of all pairwise alignments instead of using MCMC could allow for the analysis of large genomic regions.
We also used human-chimp alignments instead of human-mouse alignments as the chromatin structure of the chimp genome should be more similar to that in humans (and consequently the species of origin for each change is less important).
In addition, in Bowtie 2 alignments, options were set to report all alignments instead of in the previous experiment when the BWA default parameters were used (report first three alignments).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com