Chaston & Mangles (1997) Organizational alignment The idea that strategic vision, work processes and employee rewards are fine-tuned and in synch.
Extension of these tree alignment based ideas to a multiple alignment setting was considered in [ 52], but this unfortunately cannot handle local alignments.
In alignment with this idea, the HML subset of ER+ tumors described here is enriched for somatic mutations in MMR pathways, rather than individual genes.
The alignment-based methods utilize the idea of graph alignment that is conceptually similar to sequence alignment.
Our engineering project approach supports this idea of alignment as a process of consistency built between partial models, characterizing all of the dependencies between their constructs.
The report explains: "While an individual decision or directive action can be made in seconds, it can take weeks if not months in a large or virtual company today to get alignment on a new idea.
The model built on the idea that alignment of identical chromosomes is a natural and early consequence of semi-conservative replication, where persistent chromosomal pairing was predicted to facilitate the 'search for homology' that precedes homologous recombination.
Reviewer's report 1: Mr Alexander Panchin, Institute of Information Transmission Problems, Russian Academy of Sciences (nominated by Dr Mikhail Gelfand, Russian Academy of Sciences) The article "Next-generation phylogenomics" by Cheong Xin Chan and Mark A. Ragan addresses the idea of alignment-free methods for phylogenetic analysis using abundant next generation genome-wide data.
The basic idea of alignment-graph-based method is that false positive protein interactions are rare possible to duplicate in other species and merging two PPI networks being compared according homologous mappings between proteins can filter false positive protein interactions.
The basic idea of alignment-free methods is to use the occurrence or frequency of k-tuples (k-mers, k-grams) as sequence signatures of the studied genomes or metagenomes, and use such signatures as features for the clustering or classification.
