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These methods mainly differ in building alignment graphs, the definition of dense clusters and search algorithms.
It may be obtained by joining pairwise alignment graphs for all pairs of S-sequences.
Fiduccia-Mattheyses algorithm needs to be modified in order to deal with alignment graphs.
In alignment graphs only neighboring nodes can be merged, so MSARC just merges consecutive pairs of neighboring nodes (see Figure 5).
As a summary of graph comparisons, we have reviewed an array of methods from early single-feature, distance-based algorithms to the most current multiple network alignment graphs.
The Controller part ensures the communication between the Model and the View and is implemented by different Cytoscape Task classes, one for each process performed by GASOLINE (i.e. checking file format, computing alignments, importing networks, protein description and GO annotations, building the alignment graphs).
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The difference is that the former uses MCL after constructing alignment graph while the latter uses it before aligning with the other PPI network.
A noteworthy property of the alignment graph is that each genomic segment that is aligned without gaps in all pairwise alignments is represented as a single vertex in the graph.
Alignment graph of core housekeeping genes.
Those existing alignment-graph-based methods differ in the strategies taken to construct alignment graph and to clustering the alignment graph.
The edges in the alignment graph represent conserved interactions.
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