In case the alignment is disrupted, the performances of the anatomy-based reconstructions are comparable to those of the reconstructions simply enhanced with an edge-preserving prior.
Only when enough whiskers have been trimmed to isolate a supra-barrel from those that interact laterally with it, will somatotopic alignment be disrupted.
In the event this alignment is disrupted (as seen in several nob mutants) the synaptic morphology is usually drastically affected and/or either pre- or post-synaptic markers do not reveal staining in the synaptic layer.
Interestingly, these phenotypes are quite distinct from those observed in the Augmin mutant wac, which does not appear to have a reduced spindle area, where no defects in D-TACC localisation are apparent, but where chromosome alignment is disrupted (Meireles et al., 2009).
Thus by introducing local misalignments, the candidate sequence is globally aligned to the template alignment without disrupting the length of the template alignment.
Alignments were processed in order of increasing E-value, to prevent lower quality alignments from disrupting formation of families using higher quality alignments.
However, in the armF1a, GSK3; aPKC triple mutant, denticle and cell alignment were significantly disrupted (Fig. 4C).
Conversely, when your life's patterns are in disarray, they will quickly manifest as disrupted Time Alignment and that's the real secret benefit of developing this powerful skill: it tells you when your life is out of whack.
Boxed areas highlight the severely disrupted BG alignment and Purkinje cell patterning.
Expression of FKBP-hDyn at very high expression levels disrupted chromosome alignment and resulted in defects in spindle morphology, independently of AP20187 addition.
The portion of I-280 east of Newark was planned onto an alignment that would disrupt the fewest homes and would utilize existing railroad and utility right-of-way.
