Sentence examples for alignment defects from inspiring English sources
The early defect in OFT elongation is likely to underlie the subsequent ventriculoarterial alignment defects observed in fetal Hes1−/− hearts.
Remaining prometaphases displayed alignment defects, indicative of a rescue from the lack of KT-MT interaction (Figure 2B, graph).
Analysis of Hes1 mutant hearts at embryonic day 15.5 reveals outflow tract alignment defects including ventricular septal defects and overriding aorta.
aPKCAA did not cause any apparent apical-basal phenotype, but in contrast to aPKCΔN (Fig. 6C), aPKCAA did cause denticle alignment defects (Fig. 6D).
Previous studies have reported that GSK3 inhibition results in a delay in mitotic exit, and this phenotype has been largely attributed to chromosomal alignment defects [3], [5].
Loss of Hes1 therefore affects two critical cell populations entering the arterial pole of the heart, the SHF and cardiac neural crest cells, leading to impaired heart tube elongation and arterial pole alignment defects at later stages of development.
We confirmed the microtubule alignment defect caused by oMAP4 depletion results by tracking growing microtubule ends labelled with EB3-tdTomato.
In addition, we find that the alignment defect of GAK-depleted cells can only be reverted by variants of GAK that are able to recycle clathrin from endosomes.
RNAi-resistant GFP-CENP-Mwt localized to kinetochores and rescued the severe chromosome alignment defect caused by the depletion of endogenous CENP-M by RNAi, as well as kinetochore localization of CENP-I, demonstrating the specificity of the RNAi-based depletion of CENP-M.
Despite this significant size decrease, we did not observe any obvious problems with mitotic timing, metaphase chromosome alignment, or defects during anaphase such as lagging chromosomes.
The heritability estimate was high for prevalent bone marrow lesions and independent of other factors including knee pain, knee alignment, chondral defects, and ROA, suggesting that they are under independent genetic control, with at most a small shared genetic component.
