Alignment component is based on a consensus algorithm.
Modules with high functional coherence can be produced by assigning a relatively high weight to the functional similarity-based alignment component (see Supplementary Fig. 5), while higher weights for the graph-based component will identify larger modules.
Although this may appear to agree with the fact that functional assays suggest that both variants are at least partially functionally comprised, it should be noted that the posterior probabilities were driven by the sequence alignment component of the analysis.
It has been shown that a sequence identity threshold of 90% minimizes the Type I and Type II clustering errors introduced by the sequence alignment component of the clustering process (Wang et al., 2004).
Full length and standing anteroposterior, lateral and Merchant's view were acquired at each follow-up visit, and assessed for limb alignment, component positioning, and for any features of loosening.
The sequence data has been deposited in a public data base [GenBank: SAMN02203196-SAMN0223319]. Illumina WGS data sets were aligned against the Mu50 and 04-02981 reference genomes [ 13, 14] using the short-read alignment component of the Burrows-Wheeler Aligner (BWA) alignment tool [ 15].
In the current study, CN-TKA provided proper radiographic and functional results without the need for additional osteotomy, and no significant differences with regards to limb alignment, component position and functional outcomes were noted between both techniques even at a mean follow-up of 6.2 years.
Therefore, Illumina whole-genome sequence data sets were aligned against the chromosome of a published poultry associated sequence type (ST) 5 S. aureus reference genome (strain ED98; GenBank accession no. NC_013450 ) using the short-read alignment component of the Burrows-Wheeler Aligner [ 28].
The ITools suite consists of pre-alignment components that handle morphosyntactic tagging, statistical processing and a training phase involving manual and interactive word alignment.
The selection of non-conductive textile component such as Polyester and Acrylic/Wool was carried out just to highlight the impacts of alignment of components regardless of their fibre type.
