The phrase "alignment challenging" is correct and usable in written English.
It can be used in contexts where you are discussing difficulties or complexities related to achieving alignment in various situations, such as project management or team dynamics.
Example: "The team faced alignment challenging due to differing priorities among departments."
Alternatives: "alignment difficulties" or "alignment issues".
However, some of the clusters with the strongest evidence of positive selection had alignments with many indels, which makes alignment challenging.
Besides the low resolution and SNR of subtomograms, distortions due to missing data (ie, the missing wedge effect) make subtomogram alignment challenging, and these effects must be explicitly considered in the alignment process.
There have been wide range of computational algorithms applied to the sequence alignment challenge.
Pickering and Garrod (2004 21) state that their model of interactive alignment "challenges linguists to come up with a more flexible account of grammar capable of capturing linguistic constraints on linked sentence fragments".
This entails a managerial alignment challenge translating macro level quality definitions into different local contexts.
Using sequence data produced from the reference individual, we minimized alignment challenges that are due to genetic variation among individuals.
These data allowed us to directly compare reads to the reference assembly without alignment challenges due to genetic variation between the reference and the resequenced genome.
In particular, we observed a noticeable increase in out of focus light and increased aberrations and alignment challenges for spots away from the center.
As well as generating continuous controversy, the BRCA1 gene presents a particularly interesting set of alignment challenges due to a disproportionately high concentration of INDELs greater than eight nucleotides in length.
The study showed a managerial alignment challenge as the conceptualization differed across system levels (macro-meso-micro), among professional groups (nurses, doctors, managers), and between the studied micro systems (maternity, oncology, orthopaedics, elderly care, intensive care, and geriatrics).
But even with the use of computer assisted navigation the tibial rotational alignment is challenging and highly variable [ 63].
